O maior Tributo ao Rei do Rock Elvis Presley acontecerá no último dia deste mês, 31 de maio, uma sexta-feira. O palco será a AABB, em Tirol, e o protagonista da festa será Sávio de Luna, intérprete que encarnará a obra de Elvis com pesquisa profunda de seu estilo e timbre vocal. O show tem início às 20h. Ingresso individual a R$ 50 ou a mesa por R$ 160. Vendas na secretaria da AABB.
O repertório está repleto de sucessos contido nas três grandes e distintas fases da carreira de Elvis Presley. Serão canções que se destacaram nos anos 50, 60 e 70, como o seu primeiro e grande sucesso que o projetou ao mundo “That’s All Right Mama”, “It’s Now Or Never”, “Kiss Me Quick”, “Suspicions Minds”, “Always On My Mind”, “Bridge Over Troubled Water”, “My Way”, dentre outros sucessos que estariam, como dizem no meio artístico da música, no Lado B de suas obras.
Sávio de Luna faz questão de enfatizar que não é “cover” do cantor, já que não imita e nem se veste igual a Elvis, mas faz uma homenagem com grande rigor e pesquisa nas interpretações do Rei do Rock. Por ser barítono como Elvis Presley, suas interpretações se destacam pela similaridade de sua voz em vários momentos das interpretações, mas ainda assim mantém sua originalidade e características próprias de sua voz.
Sávio de Luna
Sávio sempre teve vocação para a música desde jovem e adolescente. Sua família também tem um histórico musical, embora tenha feito carreira profissional nacional e internacionalmente na Dança, onde começou seus estudos neste campo com o saudoso professor Edson Claro, que o preparou para o Ballet Teatro Guaíra na cidade de Curitiba e, logo após, seguindo para Portugal como bailarino convidado, viajando por quase toda Europa e Ásia.
Passou a dedicar-se ao canto de forma mais profunda e profissional a partir de 2017, mas já consegue se destacar no meio musical com seu estilo e pesquisa. Atualmente é funcionário da UFRN no cargo de Coreógrafo e faz aulas de canto semanalmente com a professora Alzeny Nelo que é também diretora da Academia de Canto Rêverie. Também fez aulas de canto lírico com sua irmã Sibelle de Luna (cantora e professora profissional), com o maestro Linus Lerner (o qual o motivou a seguir com seu projeto e carreira) e já realizou vários shows e apresentações que o levou a este nível artístico atual.
Confiram uma das interpretações de Sávio de Luna, no clássico Always on my mind
https://www.youtube.com/watch?time_continue=46&v=UP8UykJqrio
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BPC 157, also known as Body Protective Compound 157, is a synthetic pentadecapeptide derived from a protein found in the stomach lining.
Its sequence consists of fifteen amino acids and it has attracted
considerable attention for its potential therapeutic effects
across a range of medical conditions, particularly those
involving tissue repair and inflammation. Over the
past decade researchers have explored BPC
157’s impact on the central nervous system (CNS), noting promising neuroprotective properties that may benefit patients with traumatic brain injury, stroke,
neuropathic pain, depression, and other neurological disorders.
Pentadecapeptide BPC 157 and the Central Nervous System
The central nervous system is an intricate network of
neurons, glial cells, blood vessels, and supporting structures.
Damage to this system can arise from ischemia, trauma, oxidative stress,
or neuroinflammation. In experimental models, BPC 157
has been shown to exert several mechanisms that could protect or restore CNS function:
Neurovascular Protection
Studies in rodent stroke models have demonstrated that oral administration of BPC 157 reduces infarct size and improves neurological scores.
The peptide bpc 157 appears to enhance endothelial integrity,
decrease blood–brain barrier permeability, and
promote angiogenesis through upregulation of vascular endothelial growth factor (VEGF) pathways.
Anti‑Inflammatory Effects
In models of traumatic brain injury, BPC 157 reduced microglial activation and
lowered pro‑inflammatory cytokines such as
TNF‑α, IL‑1β, and IL‑6. This dampening of the inflammatory
cascade helps limit secondary neuronal damage.
Neurotrophic Support
The peptide stimulates the expression of brain-derived neurotrophic factor (BDNF) and glial cell line‑derived
neurotrophic factor (GDNF). These growth factors support neuron survival, axonal regeneration, and synaptic plasticity, which are crucial for functional recovery after CNS
injury.
Modulation of the Dopaminergic System
In animal studies examining depression‑like behavior, BPC
157 restored normal dopamine turnover in the prefrontal cortex and hippocampus.
It also normalized serotonin levels, suggesting a role in mood
regulation and potential antidepressant effects.
Pain Modulation
By acting on both peripheral and central nociceptive pathways, BPC 157 has shown efficacy in reducing neuropathic pain behaviors in rodent models.
Its influence on the opioid system and reduction of substance
P release may contribute to this analgesic effect.
Clinical evidence is still emerging, but early human case reports suggest
that BPC 157 can accelerate recovery from spinal cord injuries, improve motor function after stroke, and alleviate chronic headaches associated with migraines or tension. Ongoing clinical trials aim
to establish optimal dosing regimens, safety profiles, and long‑term outcomes
in larger patient populations.
PERMALINK
In academic publishing and online databases, a permalinks refers to
a permanent URL that provides a stable reference to a
specific piece of content such as a research article, dataset, or
review. For BPC 157 studies, researchers often use DOI (Digital Object
Identifier) links, which act as permalinks ensuring that even if
the hosting website changes, the resource remains accessible through
its unique identifier. When citing BPC 157 literature,
it is advisable to include the DOI or a permanent link in the reference list so that readers can reliably locate the
original study.
Jakša Vukojević, MD, PhD
Dr. Jakša Vukojević is a prominent figure in regenerative
medicine and peptide research. Holding both medical doctor and doctoral degrees,
he has contributed significantly to the scientific understanding of BPC 157’s mechanisms and therapeutic potential.
His work includes:
Preclinical Investigations: Dr. Vukojević conducted extensive animal studies on BPC 157’s effects on tendon healing, ligament repair,
and neural regeneration, demonstrating accelerated tissue repair and reduced inflammation.
Clinical Trials: He has overseen early phase clinical trials exploring
BPC 157 for chronic tendinopathies, osteoarthritis, and spinal injuries.
These trials have reported improved pain scores, functional outcomes, and
patient satisfaction with minimal adverse events.
Mechanistic Research: His laboratory has dissected the signaling pathways modulated by BPC 157, including the nitric oxide
synthase (NOS) system, AMP‑activated protein kinase (AMPK),
and the PI3K/Akt cascade. Understanding these pathways helps explain the peptide’s multi‑organ protective
effects.
Publications and Reviews: Dr. Vukojević has authored several peer‑reviewed articles and comprehensive reviews on BPC
157, emphasizing its safety profile, pharmacokinetics, and potential for clinical translation across neurology, orthopedics, and
gastroenterology.
His contributions have helped shape the current
perception of BPC 157 as a versatile therapeutic agent with particular promise in central
nervous system disorders. Researchers and clinicians continue to reference
his findings when designing protocols, interpreting data, or advocating
for further investigations into this promising peptide.
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Anavar is the brand name for oxandrolone, a synthetic anabolic steroid that is
widely used in medical and bodybuilding circles. Although it has a reputation for being one of the
mildest steroids on the market, it still offers powerful muscle‑building effects when combined with creatine supplementation. Many athletes find that pairing Anavar with creatine enhances gains
by boosting water retention in the muscles and
increasing energy availability during workouts.
Oxandrolone is chemically derived from dihydrotestosterone
(DHT) and is known for its relatively low androgenic activity
compared to other anabolic steroids. This makes it
a popular choice for those who want significant muscle growth while minimizing
side effects such as acne, hair loss, or prostate enlargement.
In clinical settings, oxandrolone is prescribed for patients who have
experienced weight loss due to trauma, surgery, or
chronic infections, and for individuals recovering from severe burns or radiation therapy.
Indications for the use of oxandrolone include promoting weight gain in malnourished patients, reducing catabolism after major surgeries, treating bone density loss, and assisting with muscle wasting disorders.
Because of its safety profile, it is also used by athletes to help preserve lean body mass during cutting phases or when trying to recover from injuries.
The dosage for oxandrolone varies depending on the desired outcome.
For medical purposes, a typical starting dose might be 2.5 to 10 milligrams per day.
In bodybuilding contexts, users often take doses ranging from 20 to
40 milligrams daily, split into two or three smaller intakes
throughout the day to maintain steady blood levels.
Some advanced protocols may push doses up to 60 milligrams, but this increases
the risk of liver strain and other side effects.
When combining oxandrolone with creatine, it is common practice to start with a loading phase of creatine monohydrate at around 20 grams per day for
five to seven days. After the loading period, maintenance doses of 3 to 5 grams per day are recommended.
This approach maximizes muscle phosphocreatine
stores and improves ATP regeneration during high‑intensity
training sessions.
The typical protocol for pairing Anavar with creatine involves a
few key steps:
Begin Creatine Loading – Consume 20 grams daily, divided into four equal
doses of 5 grams each. Drink plenty of water to support kidney function.
Start Oxandrolone – Take the desired milligram dosage
in two or three smaller servings (e.g., 10 mg twice a day for
a 20 mg total dose). This helps reduce potential gastrointestinal upset and maintains more consistent hormone levels.
Maintain Creatine – After the loading phase, continue with 3 to 5 grams daily.
Timing is flexible; many athletes prefer taking
it post‑workout to aid recovery.
Monitor Liver Function – Periodically check liver
enzymes (ALT, AST) during cycles that exceed 20 mg per day, as oxandrolone can place mild stress on the liver.
Hydration and Diet – Adequate protein intake (1.2–1.6 grams per
kilogram of body weight) and a balanced diet support muscle repair.
Staying well hydrated also helps mitigate any fluid retention side effects
from creatine.
In terms of cycle length, many users opt for 8 to 12 weeks on Anavar combined with creatine, followed by a post‑cycle therapy (PCT) if they plan to use other anabolic agents
or are concerned about testosterone suppression. However, because oxandrolone is
relatively mild, some individuals choose to cycle it continuously over longer periods while monitoring
liver health.
Side effects associated with oxandrolone include nausea,
headache, and in rare cases, changes in cholesterol levels (increased LDL and decreased HDL).
When combined with creatine, the most common complaints are
mild bloating or water retention in the early days of loading.
Long‑term use at high doses may cause liver strain, so it is
crucial to stay within recommended limits.
Overall, pairing Anavar with creatine can be a highly effective strategy for
athletes seeking muscle definition and strength
without excessive androgenic side effects. By carefully managing dosage, timing, and monitoring health markers,
users can maximize the benefits of both compounds while maintaining
safety.
References:
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Ipamorelin is a synthetic peptide that has gained popularity among
athletes and bodybuilders for its potential to stimulate growth hormone release without the excessive side effects sometimes seen with
other analogues. While it can promote muscle growth, fat loss, improved recovery, and
overall vitality, users should be aware that long‑term use may bring about
a range of physiological changes. Below is an in‑depth look at
what those changes might entail, why they matter, and how you can approach using this peptide
responsibly.
Understanding Ipamorelin: Benefits and Side Effects
The primary advantage of ipamorelin lies in its selective
stimulation of the growth hormone secretagogue receptor (GHS-R1a).
This action results in a controlled surge of natural human growth
hormone (HGH) levels, which is associated
with increased protein synthesis, enhanced collagen production, and improved tissue repair.
Users often report better joint health, reduced fatigue, and a
more youthful appearance after consistent cycles.
However, as with any hormone‑modulating agent, the body’s feedback
mechanisms can become disrupted over time. Long‑term administration of ipamorelin may lead to the following side
effects:
Hormonal Imbalance
Continuous stimulation of growth hormone release can cause downregulation of the natural GHS-R receptors.
When the peptide is discontinued, the body might experience a temporary drop in endogenous HGH
production, potentially leading to fatigue, decreased muscle mass, and mood
changes.
Insulin Resistance
Growth hormone has counter‑acting effects on insulin sensitivity.
Prolonged elevation of HGH can reduce glucose uptake by cells, increasing circulating blood sugar levels.
Over months, this may progress toward prediabetes or type 2 diabetes, especially in individuals with a family history of metabolic disorders.
Edema and Water Retention
Growth hormone promotes sodium retention in the kidneys. Users who have taken ipamorelin for extended periods sometimes notice puffiness around the face, ankles, or hands.
While often mild, persistent edema can be uncomfortable and may signal underlying renal stress.
Acromegaly‑Like Symptoms
Although rare with therapeutic doses, excessive HGH secretion over long durations can lead to soft tissue swelling,
enlarged fingertips or toes, and joint pain—symptoms reminiscent of acromegaly.
Monitoring growth hormone levels via blood tests can help
detect early signs.
Sleep Disturbances
Growth hormone is typically secreted during deep sleep cycles.
High exogenous stimulation may interfere with natural secretion patterns, potentially causing insomnia or fragmented sleep.
Poor sleep quality can in turn affect recovery
and overall well‑being.
Cardiovascular Stress
Elevated HGH levels have been linked to increased heart
rate variability and changes in lipid profiles. Over an extended period, this could raise
the risk of hypertension or atherosclerosis, particularly if combined with other stimulants or a high‑fat diet.
Mood Alterations
Hormonal fluctuations influence neurotransmitter systems.
Some users report mood swings, anxiety, or mild depressive symptoms during long‑term ipamorelin use,
likely tied to shifts in growth hormone and insulin pathways.
Trusted, Verified Peptides
When selecting a peptide for therapeutic or performance purposes, it is
essential to rely on reputable suppliers that adhere to strict manufacturing standards.
Look for certifications such as GMP (Good Manufacturing Practice) and third‑party
testing results that confirm purity and potency. A verified product ensures that you are
receiving a compound free from contaminants that could exacerbate side effects or
introduce new health risks.
Key indicators of a trustworthy source include:
Transparent disclosure of batch numbers, expiration dates,
and manufacturing sites.
Availability of detailed certificates of analysis (COAs) for each shipment.
Positive reviews from experienced users who have documented their results.
A clear policy on returns, refunds, and customer support in case of adverse reactions.
You May Also Like
If you are exploring peptides to enhance recovery or longevity,
consider evaluating alternatives that offer a more favorable safety
profile. Peptides such as CJC‑1295 (with DAC) provide sustained growth hormone release
but with a lower risk of acute side effects. Similarly, Melanotan II can aid in skin protection and aesthetic improvement
without directly affecting the endocrine system.
For those interested in metabolic support, look into peptides that target adiponectin or ghrelin pathways,
which can help regulate appetite and energy expenditure without significantly
altering insulin sensitivity. Lastly, always pair peptide therapy
with a balanced diet, regular exercise, and periodic blood work to monitor
hormone levels and overall health status.
Uma correção a ser feita, o texto diz erroneamente que Elvis era Barítono, em verdade ele inicialmente era Tenor, e com o passar dos Anos foi engrossando a Voz, tornando-se Barítono. Importante, creio, já que é um informativo.