O médico Aldo Medeiros, que irá coordenar o curso de Medicina do UNI-RN, acaba de ser eleito membro correspondente da Academia Nacional de Medicina (ANM). A eleição ocorreu na última quinta-feira, dia 18, no Rio de Janeiro, onde fica a sede da entidade.
Na manhã desta segunda-feira, 22, durante reunião com o reitor do UNI-RN, professor Daladier Pessoa Cunha Lima, para tratar sobre o curso de Medicina na Instituição, a eleição de Aldo Medeiros foi motivo de comemoração.
“Quando convidamos o doutor Aldo Medeiros para coordenar o curso de Medicina do UNI-RN já sabíamos das suas habilidades e competência para assumir essa missão. A sua eleição, agora, para a Academia Nacional de Medicina, que é uma das mais prestigiadas entidades de classe do país, e onde estão os maiores nomes da Medicina do Brasil, só nos dá a certeza de que fizemos a escolha certa”, pontuou o professor Daladier.
A diplomação dos novos membros da ANM está marcada para 8 de dezembro, na sede da instituição, no RJ. A ANM, fundada ainda no reinado de D. Pedro I, em 1829, é a mais antiga instituição científico-cultural do Brasil.
Aldo Medeiros
Aldo Medeiros possui graduação em Medicina pela UFRN, mestrado em Cirurgia Gastroenterológica pela Universidade Federal Fluminense, mestrado em Cirurgia Geral pela Universidade Federal do Rio de Janeiro e doutorado em Cirurgia Geral pela Universidade Federal do Rio de Janeiro.
Também é membro da Academia Norte-rio-grandense de Ciências, membro da Academy of Surgical Research (USA), membro emérito do Colégio Brasileiro de Cirurgiões e Presidente da Regional RN da Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia.
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Ipamorelin and CJC‑1295 are two popular growth hormone secretagogues used
by athletes, bodybuilders, and individuals seeking anti‑aging benefits.
While they can stimulate the pituitary gland to release more endogenous growth hormone (GH),
their use is not without risk. The side effects that may arise depend on dosage, frequency of administration, individual sensitivity, and
whether the peptides are combined with other substances.
Ipamorelin/CJC 1295 Dosage: Synergistic Effects for Growth Hormone
Release
When used together, CJC‑1295 (a long‑acting
growth hormone releasing peptide) and Ipamorelin (a short‑acting GH secretagogue) can produce a pronounced spike in circulating growth hormone.
A typical therapeutic protocol might involve injecting 200 µg of CJC‑1295 once per day and 100 µg of Ipamorelin twice
daily, spaced roughly 8–12 hours apart. For anabolic or anti‑aging
purposes, some users administer higher doses—up to 400 µg
of each peptide—though this increases the risk of adverse events.
The synergistic effect arises because CJC‑1295 sustains pituitary stimulation for up to 24 hours, while Ipamorelin provides
a rapid, high peak that can be timed around workouts or sleep cycles.
Because growth hormone influences insulin‑like growth factor‑1 (IGF‑1) production in the liver, elevated IGF‑1 levels are
often measured as an indicator of effective dosing.
Understanding Peptides
Peptides are short chains of amino acids linked by peptide bonds; they can function as hormones, neurotransmitters,
or signaling molecules. In medical and research contexts,
synthetic peptides cjc 1295 and ipamorelin side effects like CJC‑1295 (a 44‑amino‑acid analog) and Ipamorelin (a pentapeptide) are engineered to mimic natural growth hormone‑releasing
factors but with improved stability and potency. Peptides are typically delivered via subcutaneous injection because
they cannot survive the acidic environment of the stomach when taken orally.
What Are Peptides?
Peptides occupy a middle ground between small
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ligands for specific receptors on target cells, initiating
intracellular cascades that modulate metabolism, cell growth, or immune function. The length of a peptide influences its pharmacokinetics: short peptides are cleared quickly by
the kidneys, while longer sequences may be protected from rapid degradation. This distinction is why CJC‑1295 contains modifications (such as a fatty acid chain) to extend its half‑life,
whereas Ipamorelin remains short and acts transiently.
Common Side Effects
Injection Site Reactions – Redness, swelling, itching, or
bruising can occur at the subcutaneous injection site.
Repeated injections in the same area may lead to fibrosis or lipodystrophy.
Water Retention (Edema) – Growth hormone promotes
sodium and water retention, potentially causing puffy hands, feet, or
a bloated feeling, especially during high‑dose regimens.
Joint Pain and Muscle Soreness – Elevated GH levels can increase the production of IGF‑1, which in turn stimulates connective tissue turnover; some users report aches in knees, hips, or shoulders.
Headaches and Migraine Episodes – Rapid
hormonal shifts may trigger migraines or tension headaches in susceptible individuals.
Increased Appetite – Growth hormone can influence
satiety signals, leading to an elevated desire for food and potential weight
gain if caloric intake is not managed.
Insulin Resistance – Chronic high GH exposure has been linked
to impaired glucose uptake; users may develop higher fasting blood
sugar or insulin levels over time.
Hormonal Imbalance – Prolonged stimulation of the pituitary can alter the secretion patterns of other hormones such
as prolactin, testosterone, and thyroid hormones, potentially causing mood swings
or libido changes.
Less Common but Serious Risks
Cardiovascular Effects – Long‑term use may increase blood pressure or alter lipid profiles; regular monitoring of cholesterol and heart function is advisable.
Cancer Risk – Because IGF‑1 promotes cell proliferation, there is
theoretical concern that sustained high levels could stimulate tumor growth in predisposed
individuals. No definitive human studies confirm this risk, but caution is warranted for those with a history of cancer.
Hypothalamic–Pituitary Axis Suppression – Very high
doses or prolonged use can blunt the natural GH secretion cycle,
leading to withdrawal symptoms when therapy
stops.
Managing Side Effects
Rotating Injection Sites – Use different areas (abdomen,
thigh, upper arm) and follow proper hygiene to reduce
local reactions.
Hydration and Electrolyte Balance – Drink plenty of water
and monitor sodium intake to counteract edema.
Blood Sugar Checks – Perform fasting glucose or HbA1c tests regularly if you
have risk factors for diabetes.
Regular Hormonal Panels – Periodic assessment of IGF‑1, testosterone, prolactin,
thyroid function, and cortisol can detect imbalances early.
Dietary Adjustments – Maintain a balanced diet with controlled caloric
intake to offset appetite increases; consider protein‑rich meals
to support muscle anabolism without excess carbs.
Alternatives and Adjuncts
Some users pair CJC‑1295/IPamorelin with selective androgen receptor modulators (SARMs) or other peptide
cocktails, which can amplify both anabolic
effects and side effect profiles. If you experience
significant adverse reactions, consider reducing dosage, shortening the treatment window, or discontinuing one of the peptides.
Conclusion
While CJC‑1295 and Ipamorelin offer a potent means to elevate growth hormone levels, they carry a spectrum of potential side effects ranging from mild injection site discomfort to
more serious metabolic disturbances. A thoughtful approach—starting with low doses, monitoring clinical
markers, and adjusting protocols based on individual response—can help mitigate
risks while allowing users to reap the benefits of enhanced GH release.
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