A Sociedade Amigos da Pinacoteca tem se destacado na cena cultural norte-rio-grandense como um agrupamento de pessoas interessadas em apoiar e fomentar atividades intelectuais e artísticas como o anual Salão Dorian Gray de Arte Potiguar, mas também no apoio aos iniciantes ou talentosos nos seus diversos ofícios das múltiplas formas de artes.
E para celebrar o Dia Nacional da Poesia, comemorado ontem (14), apresenta oito vídeos onde alguns poetas declamam um poema de sua lavra. Tendo aderido gentilmente ao projeto por meio de convite feito por Iapery Araújo e Márcio de Lima Dantas.
“Percebemos, por apenas um recorte de um meio onde afloram tantos poetas, que chantamos na planície da poesia qualidade que nada fica a dever, nem por perto, nem alhures”, comentou a professora Isaura Rosado.
Os vídeos vão circular no instagram @amigosdapinacoteca e no youtube da Sociedade Amigos da Pinacoteca e conta com a Participação de:
Adriano de Sousa,
Antônio Ronaldo
Carito Cavalcanti
Márcio Simoes
Márcio de Lima Dantas
Oreny Júnior
Thiago Alves
Victor H de Azevedo
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BPC‑157 is a synthetic peptide that has been studied for
its potential to accelerate tissue repair, reduce inflammation,
and promote healing of tendons, ligaments, muscles, nerves,
and gut tissues. Because it is not yet approved by major regulatory agencies for human use,
the dosing information available comes largely from animal studies, anecdotal reports, and limited early‑phase research.
For a 200‑pound male who wishes to explore BPC‑157 for recovery or injury management, a
careful approach that balances efficacy with safety is essential.
—
General Principles of Dosing
Weight‑Based Starting Point
Most practitioners recommend an initial dose in the range
of 0.5 mg per day divided into two or three injections (or oral doses).
For a 200‑lb male, this translates to roughly 0.23 mg per injection if
split evenly.
Frequency
Daily dosing is typical for active healing phases (e.g.,
post‑injury or surgery). Some protocols suggest tapering the frequency after 4–6 weeks once tissue integrity improves.
Route of Administration
Subcutaneous injections are most common due to ease and absorption profile.
Oral capsules exist but typically require higher doses because first‑pass metabolism reduces bioavailability.
Duration of Treatment
Short courses (2–8 weeks) are often sufficient for tendon or ligament repairs.
Chronic conditions may necessitate longer periods, but extended use should be monitored closely by a qualified professional.
Monitoring and Adjustments
Track pain levels, range of motion, swelling, and any systemic symptoms.
If improvement stalls or adverse effects appear, consider reducing the dose or extending the interval
between injections.
BPC‑157 Dosage Calculator
A practical tool that many users employ is a simple weight‑based dosage calculator.
While there isn’t an official FDA‑approved calculator, community‑built calculators typically follow
these steps:
Input Body Weight (lbs)
Enter 200 lbs.
Choose Desired Daily Dose
Select 0.5 mg or 1 mg per day as a starting point.
Select Administration Frequency
Choose 2 injections per day for subcutaneous use, or 1 capsule per day if
using oral preparations.
Calculate Injection Volume
The calculator converts the total daily dose into microliters (µL) based on the concentration of your BPC‑157 vial (commonly
0.5 mg/mL). For example:
– 0.5 mg ÷ 0.5 mg/mL = 1 mL total per day
– Split into two injections: 0.5 mL each
Generate a Schedule
The tool outputs a simple schedule (e.g., “Inject 0.5 mL subcutaneously at 8 am and 8 pm”) along with reminders for
dosage adjustments.
Because these calculators are community‑developed, it’s important to double‑check the math manually, especially when converting between milligrams, microliters, and
concentrations.
—
Practical Example Using the Calculator
Assume you have a vial of BPC‑157 at 0.5 mg/mL (a common concentration).
For a 200‑lb male:
Target Daily Dose: 1 mg
Number of Injections per Day: 2
Volume per Injection:
– 1 mg ÷ 0.5 mg/mL = 2 mL total daily
– Divided by 2 injections = 1 mL each
If you prefer a lower dose, the same steps apply with
the numbers scaled down accordingly.
—
Common Dosage Regimens Reported in Anecdotal Sources
Phase Daily Dose (mg) Frequency Duration
Acute Injury 0.5–1 mg 2 injections/day 4–6 weeks
Post‑Surgery 0.75–1 mg 2 injections/day 8–12 weeks
Chronic Tendinopathy 0.25–0.5 mg 1 injection/day 6–12 months (tapering)
These ranges are approximate and should be tailored to
individual response.
—
Safety Considerations
Allergies and Sensitivities
Some users report mild injection site reactions or transient itching.
If severe discomfort occurs, discontinue use
and consult a healthcare provider.
Interactions with Other Supplements
BPC‑157 may interact with medications that influence blood clotting or immune function. Discuss any concurrent therapies before starting.
Legal Status
In many jurisdictions, bpc 157 tb 500‑157 is considered an investigational substance.
Obtain it from reputable suppliers and verify purity via third‑party testing
when possible.
Summary
For a 200‑lb male considering BPC‑157, begin with
a conservative dose of around 0.5 mg per day split into two injections if using subcutaneous administration. Utilize a weight‑based dosage calculator to convert the desired milligram amount into injection volume
based on your vial’s concentration. Monitor healing progress and
adjust dosing frequency or quantity as needed while staying within the commonly cited ranges of
0.25–1 mg daily. Always prioritize safety,
legal compliance, and professional guidance throughout the
course.
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Ipamorelin and CJC‑1295 are two of the most popular growth hormone secretagogues used by athletes, bodybuilders, and individuals seeking anti‑aging benefits.
While they can provide significant increases in circulating growth hormone levels, their use is not without risks.
Understanding the potential side effects, especially from a medical
perspective, helps users make informed decisions about whether to incorporate these peptides into their regimen.
—
Understanding Ipamorelin Side Effects: A Comprehensive Review
Hormonal Imbalance and Endocrine Disruption
Ipamorelin stimulates the pituitary gland to release growth hormone (GH) and insulin‑like growth factor
1 (IGF‑1). Prolonged or high‑dose exposure can upset the delicate balance of other
hormones. Users may experience:
Elevated prolactin levels, which can lead to lactation in women, decreased libido, and sexual dysfunction.
Alterations in thyroid hormone production; some individuals report mild hypothyroidism symptoms such as
fatigue, weight gain, or cold intolerance.
Changes in cortisol rhythm, potentially contributing to
mood swings or sleep disturbances.
Metabolic Effects
Because growth hormone has lipolytic properties, it can influence glucose metabolism.
The main metabolic concerns include:
Insulin resistance: Some users develop higher fasting insulin levels and decreased glucose tolerance over time, which may predispose them to type‑2 diabetes.
Increased triglycerides: Elevated fat breakdown can sometimes raise circulating lipid intermediates, potentially impacting cardiovascular risk.
Local Injection Site Reactions
Ipamorelin is typically administered subcutaneously. Common local reactions involve:
Redness and swelling at the injection site that generally resolves within 24 to 48
hours.
Pain or tenderness during needle insertion or withdrawal.
Rarely, users develop a mild inflammatory reaction that may require topical steroids or antihistamines.
Cardiovascular Concerns
Growth hormone exerts effects on blood vessels. In susceptible individuals, ipamorelin can cause:
Peripheral edema: Fluid retention in extremities, especially when combined with
high GH levels.
Hypertension: Elevated blood pressure readings may appear
after prolonged use, necessitating regular monitoring.
Neurological and Psychological Effects
Some users report changes in mood or cognition, which may include:
Anxiety or irritability during the first weeks of therapy as
the body adapts to increased GH.
Sleep disturbances such as insomnia or vivid dreams due
to hormonal fluctuations.
Headaches, particularly if water retention leads to increased intracranial pressure.
Rare but Serious Complications
Although uncommon, there are serious adverse events that can arise:
Acromegalic changes: Long‑term overstimulation of GH can lead to soft tissue
swelling and bone overgrowth in the hands, feet, or face.
Tumor growth stimulation: Certain tumors may respond to higher IGF‑1 levels by accelerating
proliferation.
Key Takeaways
Dose Matters – The likelihood and severity of side effects increase with higher dosages or extended treatment periods.
Adhering to recommended protocols (e.g., 100–200 µg daily) reduces risk.
Monitoring is Crucial – Regular blood work
for GH, IGF‑1, insulin, thyroid hormones, and lipid panels helps catch imbalances early.
Injection Technique Affects Comfort – Using a
new sterile needle each time and rotating injection sites can minimize local reactions.
Lifestyle Factors Influence Outcomes – Adequate sleep,
balanced nutrition, and avoiding excessive alcohol or caffeine help mitigate many side effects.
Consult Healthcare Professionals – Prior to starting
ipamorelin, especially if you have pre‑existing medical conditions,
a thorough evaluation by an endocrinologist is advisable.
Ipamorelin Cancer Risk Assessment
The relationship between growth hormone secretagogues and cancer risk remains under investigation. Several points are important:
Biological Rationale
Growth hormone drives the production of IGF‑1, a mitogenic factor that can promote cell proliferation. Elevated
IGF‑1 levels have been linked in epidemiological studies to increased
risks for certain cancers such as breast, prostate, and colorectal.
Evidence from Animal Studies
Rodent models treated with GH secretagogues occasionally show accelerated tumor growth
in pre‑existing tumors or enhanced development of benign nodules.
However, translating these findings to humans is not straightforward due to species differences.
Human Data
Clinical trials involving ipamorelin are limited and typically short‑term (a few weeks).
No large‑scale randomized controlled studies have definitively shown an increase in cancer incidence among users.
Long‑term observational data are sparse.
Current Consensus
Low to Moderate Risk: For healthy individuals using standard therapeutic doses,
the risk appears low but cannot be dismissed entirely.
Higher Risk with Pre‑Existing Conditions: People who already have hormone‑responsive cancers
or a strong family history may face an elevated risk if GH/IGF‑1 levels
rise.
Practical Recommendations
Screening Before Use – A baseline evaluation of tumor markers
and imaging for those with personal or familial cancer histories can identify hidden lesions.
Periodic Surveillance – Annual check‑ups, including
PSA testing in men over 50, mammography in women, and colonoscopy as
indicated, are prudent while on therapy.
Limit Duration – Shorter courses (no more than three to six
months) reduce cumulative exposure to elevated IGF‑1.
In summary, while ipamorelin offers tangible benefits for growth hormone deficiency or anti‑aging protocols, it carries a
spectrum of side effects ranging from mild injection site reactions to serious endocrine and cardiovascular disturbances.
Its potential link to cancer remains an area of active research; thus, users should proceed with caution, maintain rigorous monitoring, and consult healthcare providers
before initiating therapy.
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