A escritora, poeta e artista plástica Jânia Souza vai lançar mais dois livros de sua autoria durante live promovida pela União Brasileira de Escritores (UBE/RN). Será nesta quarta (26) às 19h no canal de youtube da entidade, mediado pela escritora e professora Carla Alves.
PIONEIRAS traça a trajetória de três mulheres potiguares precursoras na luta feminina por direitos civis e políticos na América Latina em uma sociedade comandada por homens e por machistas. São elas, Nísia Floresta, Alzira Soriano e Celina Guimarães.
“Elas são mulheres ícones que precisam ser resgatadas no coração das novas gerações. Além disso, seus valorosos feitos devem ser reconhecidos e aplaudidos pela humanidade”, enfatizou Jânia.
“Pioneiras” conta com apresentação da feminista Joluzia Batista Jô Batista, orelha da poeta e escritora Rizolete Fernandes. tem quarta capa da poeta e escritora Anchella Monte, projeto editorial e capa de Bruno Obos e sai pela Editora B3S.
O livro recebeu a terceira colocação no Prêmio de Literatura Nísia Floresta da Fundação José Augusto, na categoria Vozes Femininas.
Na última sexta-feira (21), Jânia Souza participou de live com Sônia Miquelin, presidente da Associazione Culturale Internacionale Mandala, italiana, para lançar o livro Pioneiras.
O Jumentinho Abel
O outro livro traz de volta o talento de escritora de livros infantis com a fábula “O Jumentinho Abel”, que trata do relacionamento entre professor e aluno valorizando a importância dos ensinamentos para o crescimento saudável e ajustado ao indivíduo e ao coletivo da criançada.
O livro recebeu o Prêmio de Literatura Infantil Carolina Wanderley. E assim como a obra “Pioneiras”, foi contemplado em Edital da FJA Lei Aldir Blanc RN.
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detailed specifications, including purity grades and certificates of analysis
from third‑party testing laboratories. Look for vendors that list their batch numbers and provide traceability records.
Dosage protocols reported in animal studies range from 10 to 50
micrograms per kilogram of body weight, usually administered via subcutaneous injection or oral gavage.
Human users who have experimented with the peptide often report using
lower doses—typically between 1 and 5 micrograms per day—for
a period ranging from two weeks to several months.
However, without established pharmacokinetic data in humans, it is
difficult to predict how much of the peptide actually reaches target
tissues or what the optimal dosing schedule might be.
Potential risks and side effects are not well
documented. In animal models, BPC 157 has been shown to be relatively safe with minimal adverse events
at the doses tested. Nonetheless, because the peptide
can influence vascular dynamics and inflammatory pathways, there
is a theoretical risk of unintended interactions—especially if you have underlying
cardiovascular conditions or are taking other medications that affect blood flow or
clotting. Some anecdotal reports mention mild nausea, dizziness,
or transient headaches after injection, but these symptoms are not consistently
observed.
Legal status varies by country. In the United States, BPC 157 is
classified as a research chemical and is not approved
for human consumption. The Food and Drug Administration has
issued warnings against its use outside of clinical trials.
Similar restrictions exist in many European countries,
where it may be considered an investigational substance.
Always check local regulations before purchasing or using the peptide to avoid legal complications.
Alternatives that have more robust evidence base for tissue repair
include well‑established supplements such as collagen peptides, glucosamine,
chondroitin, omega‑3 fatty acids, and vitamin C.
These nutrients support connective tissue health, reduce oxidative stress, and promote natural healing pathways without the regulatory uncertainty
surrounding BPC 157.
In summary, while BPC 157 shows intriguing potential for enhancing recovery in preclinical studies, its use in humans remains experimental.
If you are considering it as a supplement to improve healing, weigh
the lack of clinical data, possible safety concerns, and legal restrictions against any anecdotal
benefits reported by other users. Consulting with a qualified healthcare professional before initiating
any new therapeutic compound is strongly advised.
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Sermorelin is a synthetic peptide that mimics the natural growth hormone releasing hormone (GHRH) produced
by the hypothalamus. By stimulating the pituitary gland to release more growth hormone, it offers therapeutic benefits for conditions
such as growth hormone deficiency, aging-related declines in anabolic activity, and certain endocrine disorders.
Although many patients experience improvements in energy levels,
muscle mass, and overall well‑being, there are concerns about potential side effects that could arise from prolonged exposure to elevated
growth hormone levels, particularly the possibility of increasing cancer risk.
Sermorelin gh-related side effects Effects:
Is There a Cancer Risk?
Growth hormone (GH) and its downstream mediator insulin‑like growth
factor 1 (IGF‑1) play central roles in cellular proliferation, differentiation, and survival.
Because many tumors rely on these pathways for growth and resistance to apoptosis,
there is legitimate scientific interest in whether chronic stimulation of GH release could predispose individuals to malignant transformations.
The data from clinical trials and observational
studies are mixed. Short‑term use of sermorelin has generally been associated with a favorable safety profile,
but long‑term exposure—especially at high doses or in patients
with preexisting neoplastic disease—raises questions about whether the hormone’s
mitogenic effects could tip the balance toward oncogenesis.
Several large epidemiologic analyses have examined associations between GH therapy and
cancer incidence. While some studies found no statistically significant increase in overall malignancy rates among children treated
for GH deficiency, others noted a modest rise in certain tumor types such
as thyroid carcinoma or meningioma in adults receiving growth
hormone replacement over many years. Importantly, these
findings are largely derived from data on recombinant human growth hormone (rhGH)
rather than sermorelin itself. Sermorelin is considered a more physiologic
stimulator because it triggers endogenous GH release rather than supplying exogenous hormone directly; however, the downstream signaling pathways—IGF‑1 production, mitogen‑activated protein kinase
activation, and phosphatidylinositol 3‑kinase/Akt signaling—remain identical.
The current consensus among endocrinologists is that sermorelin therapy should be carefully monitored in patients with a personal or family history of cancer, especially those who have undergone treatment for hormone‑sensitive
tumors. Regular imaging studies, thyroid function tests,
and surveillance for other malignancies are recommended during long‑term
treatment. In addition, the potential for increased insulin resistance—a known risk factor for several cancers—should be considered when prescribing
sermorelin to patients with metabolic syndrome or type 2 diabetes.
Introduction to Sermorelin Therapy
Sermorelin is typically administered by subcutaneous injection once daily,
often in the evening before sleep. The dosage is individualized based on age, baseline
GH and IGF‑1 levels, body mass index, and therapeutic goals.
Because sermorelin is a peptide, it must be stored at refrigerated temperatures and protected from light; many patients prepare their own doses using kits that include vials and needles.
The primary indications for sermorelin therapy include:
Growth hormone deficiency in children and adults, confirmed by dynamic testing.
Reproductive disorders such as hypogonadism where
GH levels are low.
Age‑related decline in anabolic activity leading to sarcopenia or frailty.
Certain endocrine conditions, like hypopituitarism or pituitary adenoma sequelae.
Patients often report subjective improvements within weeks of therapy:
enhanced sleep quality, increased energy, better mood, and improved skin elasticity.
Objective measures such as lean body mass gain, decreased visceral fat, and improved insulin sensitivity
are also documented in controlled studies.
Understanding Sermorelin and its Uses
The mechanism of action for sermorelin is rooted in its structural similarity to endogenous GHRH.
Once injected, it binds to the GHRH receptor on somatotrophs in the anterior pituitary, activating adenylate
cyclase and increasing cyclic AMP production. This cascade triggers GH
secretion into circulation. Elevated circulating GH subsequently stimulates hepatic synthesis of IGF‑1, which exerts endocrine
effects by binding to IGF receptors on target tissues.
Because sermorelin’s effect is pulsatile—mimicking the natural circadian rhythm of
GH release—it avoids some of the peaks and troughs associated with continuous rhGH
infusion. This physiologic pattern may reduce the risk of adverse effects such as edema,
arthralgia, or carpal tunnel syndrome that are sometimes seen with high-dose growth hormone replacement.
In addition to its endocrine benefits, sermorelin has been explored for use in regenerative medicine.
Research into its role in wound healing, cartilage repair, and neuroprotection is ongoing, though these applications remain largely experimental at this time.
Key considerations when initiating sermorelin therapy include:
Baseline evaluation of growth hormone axis: serum GH peak after stimulation test, IGF‑1 levels, and thyroid function.
Screening for contraindications: active malignancy, uncontrolled diabetes,
or severe liver disease.
Monitoring during treatment: periodic measurement of IGF‑1 to avoid supraphysiologic exposure, assessment
of metabolic parameters (glucose tolerance, lipid profile), and vigilance for signs of fluid retention or edema.
Patients should be counseled about the possibility of mild injection site reactions—pain, redness, or swelling—which typically resolve within a day.
In rare cases, allergic reactions may occur; any sign of anaphylaxis warrants immediate medical attention.
In summary, sermorelin offers a physiologic approach to restoring growth hormone activity in patients with
deficiency or age‑related decline. While most short‑term
studies indicate a favorable safety profile, the potential for increased cancer risk—especially with prolonged use—remains an area that requires ongoing surveillance and individualized patient assessment.
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Caro Sérgio Vilar, muito obrigada pela excelente matéria sobre o lançamento dos meus livros publicados pela Lei Aldir Blanc, Edital 09/2020 da Fundação José Augusto. Gratidão
Sempre um prazer, Jânia. Sou fã!